Randomized Trialmoderate evidence
Comparative efficacy of ultrasound-guided intra-articular injection of platelet-rich plasma (PRP), hydrolyzed type I collagen, and hyaluronic acid in patients with knee osteoarthritis: a randomized controlled trial.
Future science OA·December 1, 2026·PMID 42791219
Why it mattersKnee osteoarthritis injectable options are expanding, but direct comparisons of emerging biomaterials like hydrolyzed collagen with established PRP and HA are scarce. This trial provides head-to-head efficacy data that can inform injectable selection for patients with mild to moderate disease.
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