Randomized Trialhigh evidence
Closed-loop versus conventional synchronization in spontaneously breathing adult patients- a randomized controlled study.
Journal of critical care·August 14, 2026·PMID 42600333
Why it mattersPatient-ventilator asynchrony during NIV is common and associated with worse outcomes. A closed-loop algorithm that reduces asynchrony and improves comfort without additional invasive monitoring could enhance NIV delivery in critical care settings.
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