Meta-Analysishigh evidence
Effectiveness of Selective Cyclooxygenase-2 Inhibitors for Postoperative Pain Management Using Multidimensional Pain Assessment: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Anesthesiology·September 9, 2026·PMID 42708838
Why it mattersPostoperative pain often impairs daily functioning and can transition to chronic pain. This meta-analysis provides moderate-certainty evidence that selective COX-2 inhibitors reduce pain-related interference beyond simple pain scores, supporting their role in multimodal perioperative analgesia.
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