Basic Sciencelow evidence
An aging-sensitive secreted phospholipase confers neuroprotection and cognitive resilience.
Nature neuroscience·October 15, 2026·PMID 42881225
Why it mattersCognitive decline in aging involves lipid dysregulation and neuroinflammation, yet compensatory mechanisms remain poorly defined. This study identifies a neuronal secreted factor that maintains lipid homeostasis and protects hippocampal circuits, offering a potential target for interventions aimed at preserving cognitive function in older adults.
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