Randomized Trialhigh evidence
Intravenous Tirofiban After Tenecteplase in Acute Ischemic Stroke: The INSTANT Randomized Clinical Trial.
JAMA·June 9, 2026·PMID 42100960
Why it mattersThis trial addresses a common clinical scenario where patients fail to improve after thrombolysis and lack a clear target for endovascular therapy. It provides evidence that early antiplatelet escalation with tirofiban may improve functional recovery in this underserved subgroup.
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