Cohort Studymoderate evidence
Incidence of opioid use disorder among patients prescribed long-term opioid therapy: An observational study.
Drug and alcohol dependence·October 8, 2026·PMID 42879916
Why it mattersIncident OUD during long-term opioid therapy is a critical safety concern, yet contemporary estimates using DSM-5 criteria have been lacking. These data provide clinicians with realistic risk figures for shared decision-making and may inform monitoring strategies and prevention efforts.
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