Randomized Trialhigh evidence
Pulmonary Vein Isolation vs Sham Intervention in Symptomatic Atrial Fibrillation: The SHAM-PVI Randomized Clinical Trial.
JAMA·September 2, 2024·PMID 39221629
Why it mattersThis is the first sham-controlled trial for AF ablation, providing definitive evidence that PVI's efficacy is not solely due to placebo. It strengthens the case for offering ablation to appropriate patients and informs shared decision-making.
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