Meta-Analysisvery high evidence
A systematic review and meta-analysis of the efficacy and safety of pharmacological treatments for obesity in adults.
Nature medicine·October 1, 2025·PMID 41039116
Why it mattersFor clinicians managing obesity-related pain and comorbidity, this review supports anti-obesity pharmacotherapy as more than a weight-loss tool. GLP-1–based and GLP-1/GIP therapies may offer added value in patients with osteoarthritis pain, diabetes, cardiovascular risk, sleep apnea, or fatty liver disease.
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