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Genetic architecture of a Circadian Imbalance Index: genome-wide association, phenome-wide association, and Mendelian randomisation analyses.

EBioMedicine·July 21, 2026·PMID 42481375

Why it matters

The CII offers a genetically informed composite measure of circadian disruption susceptibility that may help identify individuals at risk for cardiometabolic and mood disorders, even before clinical symptoms appear.

Infographic summary of Genetic architecture of a Circadian Imbalance Index: genome-wide association, phenome-wide association, and Mendelian randomisation analyses.
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