Pharmacological Management of Opioid Use Disorder: A Systematic Review and Network Meta-Analysis: Prise en charge pharmacologique du trouble de l'usage des opiacés : revue systématique et méta-analyse en réseau.
Canadian journal of psychiatry. Revue canadienne de psychiatrie·September 12, 2026·PMID 42731100
Why it mattersOpioid use disorder treatment decisions hinge on retention and abstinence, yet comparative effectiveness across available pharmacotherapies has been unclear. This analysis provides moderate-certainty evidence that heroin-assisted therapy and high-dose methadone outperform alternatives for retention, while buprenorphine and methadone improve abstinence—information directly relevant to selecting first-line and second-line treatments in addiction medicine and internal medicine settings.
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