Randomized Trialhigh evidence
IV Fosphenytoin for Acute Trigeminal Neuralgia: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial.
Neurology·June 9, 2026·PMID 42096672
Why it mattersAcute trigeminal neuralgia exacerbations lack evidence-based IV rescue options. This first RCT provides Class I evidence that IV fosphenytoin offers rapid, well-tolerated pain relief, filling a critical gap for patients unresponsive to oral medications or awaiting surgery.
The papers that matter, first.
MedLit ranks the medical literature into a specialty feed with concise summaries, evidence-aware triage, and visual takeaways.
§
MedLit · Evidence, Distilled