Basic Sciencemoderate evidence
Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing.
Nature·July 1, 2025·PMID 39695235
Why it mattersIt reveals a molecular pathway linking a naturally occurring metabolite to AMPK activation and anti-aging effects, offering mechanistic insight into how calorie restriction may work and potential targets for interventions.
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