Meta-Analysishigh evidence
The Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Co-Transporter-2 Inhibitors on Lean Body Mass in Humans: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
Diabetes/metabolism research and reviews·July 1, 2026·PMID 42319968
Why it mattersClinicians prescribing these agents for weight loss or diabetes should be aware that a meaningful proportion of weight lost is lean mass, which could impact metabolic health and physical function over time.
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