Randomized Trialhigh evidence
Catheter-Directed Thrombolysis in Intermediate-High-Risk Pulmonary Embolism.
The New England journal of medicine·August 31, 2026·PMID 42678032
Why it mattersIntermediate-high-risk PE carries a substantial risk of early hemodynamic deterioration despite anticoagulation. This trial provides high-quality evidence that catheter-directed thrombolysis can markedly reduce that risk without a significant increase in major bleeding, offering a potentially safer alternative to systemic thrombolysis for selected patients.
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