Randomized Trialmoderate evidence
Targeted Temperature Management at 35°C vs. 37°C for Heatstroke in ICU: A Pilot Randomized Controlled Trial.
Critical care medicine·August 6, 2026·PMID 42560130
Why it mattersHeatstroke management in the ICU lacks evidence-based temperature targets. This trial provides early safety signals that aggressive cooling to 35°C may cause harm without benefit, directly informing critical care and emergency medicine clinicians who manage severe heat illness.
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