Meta-Analysishigh evidence
Impact of Treatment Duration on the Effectiveness of Opioid Analgesia: A Systematic Review and Meta-Analysis.
The British journal of general practice : the journal of the Royal College of General Practitioners·May 7, 2026·PMID 42097637
Why it mattersIt clarifies that opioid benefits in chronic non-cancer pain are largely confined to the first month, reinforcing guideline recommendations to limit opioid duration and highlighting the risk of diminishing returns or harm with prolonged use.
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