Randomized Trialhigh evidence
Pulmonary Denervation for Heart Failure-Related Pulmonary Hypertension.
The New England journal of medicine·August 30, 2026·PMID 42670986
Why it mattersPulmonary hypertension due to left heart disease is common in heart failure and portends poor outcomes, yet no device-based therapy has proven benefit. This trial provides the first randomized evidence that pulmonary-artery denervation may reduce clinical worsening, offering a potential new intervention for a high-risk population.

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