Randomized Trialhigh evidence

Do carbon dioxide, volatile organic compounds and atmospheric pressure affect the cognitive performance of occupants in indoor environments? Results of a large-scale experiment with simulated flights.

International journal of hygiene and environmental health·June 1, 2026·PMID 42035679

Why it matters

Indoor air quality is often cited as a modifiable factor for cognitive function, especially in performance-focused settings like offices, aircraft, or high-altitude environments. This large, well-controlled trial challenges the notion that short-term elevations in CO2 and VOCs at these levels impair cognition in healthy adults, helping clinicians and advisors contextualize environmental claims.

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