Randomized Trialhigh evidence
A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment.
Alzheimer's & dementia : the journal of the Alzheimer's Association·July 1, 2026·PMID 42478598
Why it mattersNAD+ decline is implicated in Alzheimer’s disease, and NR is widely used to boost NAD+. This study provides early controlled evidence that short-term NR does not translate to cognitive or global hemodynamic benefits in aMCI, tempering expectations while hinting at regional brain perfusion effects that warrant longer investigation.
The papers that matter, first.
MedLit ranks the medical literature into a specialty feed with concise summaries, evidence-aware triage, and visual takeaways.
§
MedLit · Evidence, Distilled