Basic Sciencemoderate evidence
Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation.
Proceedings of the National Academy of Sciences of the United States of America·January 13, 2026·PMID 41512022
Why it mattersAging-related tissue decline drives morbidity, and safe rejuvenation strategies are lacking. This work identifies specific, single-factor perturbations that partially reverse cellular and tissue aging without dedifferentiation, offering potential targets for interventions aimed at extending healthspan.
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