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Pain and symptom severity outcomes in patients with cancer before and after intrathecal drug delivery: mixed model analysis in 222 cases.
Regional anesthesia and pain medicine·September 8, 2026·PMID 42710941
Why it mattersCancer pain often requires escalating systemic opioids, which can cause dose-limiting toxicity and inadequate relief. This study provides real-world evidence that intrathecal drug delivery can reduce pain and symptom burden while enabling opioid discontinuation in most patients, offering a viable alternative for those with refractory cancer pain.
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