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Comparative effectiveness of GLP-1 receptor agonists versus mineralocorticoid receptor antagonists as fourth-line pharmacological therapy in patients with resistant hypertension and overweight or obesity: a retrospective multicenter cohort study in the USA.
EClinicalMedicine·September 1, 2026·PMID 42701458
Why it mattersResistant hypertension in patients with overweight or obesity is challenging, and MRAs are standard fourth-line therapy. This study suggests GLP-1RAs may offer cardiovascular and kidney benefits beyond blood pressure lowering, potentially reshaping treatment selection in this high-risk group.
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