Randomized Trialhigh evidence
Effects of a clinical metagenomics intervention on clinical outcomes, healthcare costs, and health-related quality of life in patients with sepsis or septic shock: results of the randomized-controlled DigiSep trial.
Intensive care medicine·June 30, 2026·PMID 42377463
Why it mattersRapid pathogen identification is critical in sepsis, and mNGS offers broader detection than conventional cultures. This trial provides the first randomized evidence that mNGS may improve clinically meaningful endpoints like ventilator days and shock duration, even if a composite primary endpoint was not met.
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