Meta-Analysishigh evidence
Evaluating Reduced Use and Abstinence as Outcomes in Pharmacotherapy Trials for Stimulant Use Disorder: A Meta-Analysis of 12 Randomized Controlled Trials.
JAMA psychiatry·June 3, 2026·PMID 42234418
Why it mattersAddiction specialists lack approved medications for stimulant use disorder. This analysis suggests that using reduced use as an endpoint could identify promising treatments that would be overlooked if only abstinence is required, potentially accelerating drug development.
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