Randomized Trialhigh evidence
Effect of ketofol versus Fentanyl-Midazolam sedation on neurological recovery in traumatic brain Injury: A randomised study.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·July 22, 2026·PMID 42485824
Why it mattersSedation choice in neurocritical care may influence neurological recovery after TBI. This trial provides preliminary evidence that ketofol could improve early functional outcomes compared to a standard opioid-benzodiazepine regimen, without increasing adverse events.
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