Meta-Analysishigh evidence
Cardiovascular safety in middle-aged and older men under testosterone replacement therapy: a systematic review and meta-analysis.
Endocrine·October 6, 2026·PMID 42836912
Why it mattersTRT is widely used for hypogonadism, but its cardiovascular risk profile has been debated. This analysis suggests favorable lipid and vascular effects, yet the arrhythmia signal warrants attention when counseling patients, particularly those with pre-existing cardiac conduction issues.
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