Randomized Trialhigh evidence
A Digital Therapeutic Intervention for Negative Symptoms of Schizophrenia: A Randomized Clinical Trial.
JAMA network open·September 1, 2026·PMID 42789268
Why it mattersNegative symptoms of schizophrenia, especially motivation and pleasure deficits, lack approved pharmacotherapies and are poorly addressed by current care. This trial provides evidence that a scalable digital intervention can improve these symptoms, offering a potential adjunctive option for a difficult-to-treat domain.
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