Cohort Studyhigh evidence
Population-Level Health Benefits and Harms Associated With Buprenorphine/Naloxone vs Methadone.
JAMA network open·December 1, 2025·PMID 41632156
Why it mattersClinical guidelines have increasingly favored buprenorphine/naloxone over methadone, but this study challenges that preference by showing that methadone's superior retention may yield better population-level survival, informing more balanced treatment recommendations.
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