Cohort Studyhigh evidence
Opioid-specific risk of respiratory depression in non-cancer pain: a retrospective cohort study.
BMC medicine·July 8, 2026·PMID 42415029
Why it mattersRespiratory depression is a life-threatening opioid adverse effect, yet comparative risk data by specific opioid and dose in non-cancer pain are scarce. These findings help clinicians select safer opioids and identify high-risk combinations, particularly in hospitalized patients where monitoring is intensive but events still occur.
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