Randomized Trialhigh evidence
Effect of testosterone addition to nutrition and exercise on muscle mass in men with cirrhosis: the next trial.
Hepatology international·June 19, 2026·PMID 42319724
Why it mattersSarcopenia and frailty are common in cirrhosis and worsen outcomes. Current management relies on nutrition and exercise, but many patients respond poorly. This trial provides evidence that testosterone augmentation can meaningfully enhance muscle mass and functional status, offering a potential adjunctive strategy for a challenging clinical problem.
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