Basic Sciencemoderate evidence
Cognitive rejuvenation through partial reprogramming of engram cells.
Neuron·March 18, 2026·PMID 41672073
Why it mattersCognitive decline in aging and Alzheimer's disease lacks therapies that target underlying cellular dysfunction. This work demonstrates that partial reprogramming of memory-specific neurons can restore cognitive function in mouse models, opening a potential avenue for regenerative interventions in neurodegenerative conditions.
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