Cohort Studymoderate evidence
Epigenetic ageing is accelerated in drug-resistant epilepsy and dynamically modulated during ketogenic diet therapy.
EBioMedicine·September 1, 2026·PMID 42632233
Why it mattersDrug-resistant epilepsy is linked to accelerated biological aging, and ketogenic diet therapy may influence aging rate dynamics. The association between DunedinPACE trajectory and quality-of-life improvement suggests that rate-based epigenetic clocks could capture short-term systemic responses to metabolic interventions, offering a potential biomarker for patient-centered outcomes beyond seizure control.
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