Randomized Trialhigh evidence

Efficacy and safety of allogeneic mesenchymal precursor cells with and without hyaluronic acid for treatment of chronic low back pain: a prospective, randomized, double blind, concurrent-controlled 36-month study.

The spine journal : official journal of the North American Spine Society·September 1, 2025·PMID 40174800

Why it matters

This study provides 36-month safety and efficacy data on a minimally invasive, nonopioid regenerative therapy for discogenic low back pain, highlighting a potential treatment option for patients with shorter chronic pain duration who have failed conservative care.

Infographic summary of Efficacy and safety of allogeneic mesenchymal precursor cells with and without hyaluronic acid for treatment of chronic low back pain: a prospective, randomized, double blind, concurrent-controlled 36-month study.
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