Randomized Trialhigh evidence
Supervised multimodal prehabilitation of older patients with frailty or prefrailty before elective surgery: a multicentre randomised controlled outcome assessor-blinded trial.
The lancet. Healthy longevity·September 15, 2026·PMID 42743945
Why it mattersFrailty is a major perioperative risk, and prehabilitation is widely promoted to improve outcomes, but evidence on functional independence is limited. This large trial shows that a short, supervised multimodal program did not reduce care dependency at 12 months, challenging assumptions about universal prehabilitation for frail older surgical patients.
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