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Accelerated Epigenetic and Inflammatory Aging and Intrinsic Capacity.

JAMA network open·July 1, 2026·PMID 42475093

Why it matters

Intrinsic capacity is a WHO-developed composite of physical and mental functions that predicts healthy longevity. Understanding its molecular drivers can help clinicians identify patients at risk for functional decline earlier and target interventions to preserve function across the lifespan.

Infographic summary of Accelerated Epigenetic and Inflammatory Aging and Intrinsic Capacity.
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