Cohort Studyhigh evidence
Psychiatric morbidity following liothyronine exposure in autoimmune hypothyroidism: a Swedish nationwide cohort study.
Journal of the Endocrine Society·July 1, 2026·PMID 42255516
Why it mattersDespite rising off-label use of LT3 for persistent symptoms, this large real-world study suggests an association with increased psychiatric morbidity, raising concerns about safety and highlighting the need for cautious patient selection and monitoring.
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