Randomized Trialhigh evidence
Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine Replacement: A Randomized Clinical Trial.
JAMA·May 28, 2024·PMID 38696203
Why it mattersMany patients fail initial smoking cessation pharmacotherapy, yet evidence on next-step strategies is limited. This trial provides high-quality data to guide clinicians when first-line treatment does not achieve abstinence.

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