Randomized Trialhigh evidence

An Optimization Randomized Clinical Trial to Identify an Effective, Efficient Smoking Cessation Intervention in the Context of Lung Cancer Screening: Cessation and Screening to Save Lives (CASTL).

Chest·July 8, 2026·PMID 42419585

Why it matters

Lung cancer screening encounters are a critical touchpoint for smoking cessation, yet optimal, resource-sensitive interventions remain undefined. This trial provides comparative effectiveness and cost data to help clinicians select efficient tobacco treatment strategies for this high-risk, highly addicted population.

Infographic summary of An Optimization Randomized Clinical Trial to Identify an Effective, Efficient Smoking Cessation Intervention in the Context of Lung Cancer Screening: Cessation and Screening to Save Lives (CASTL).
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