Meta-Analysishigh evidence
Efficacy and Safety of Systemic Prophylactic Antibacterials in Mechanically Ventilated Patients: Systematic Review and Meta-Analysis.
Critical care medicine·June 1, 2026·PMID 42223318
Why it mattersVentilator-associated pneumonia remains a major ICU complication, and while selective digestive decontamination is known to help, the isolated role of IV antibiotics is unclear. This analysis clarifies that systemic prophylaxis reduces VAP, especially early VAP, without clear mortality benefit, informing antimicrobial stewardship decisions.
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