Meta-Analysishigh evidence
Alzheimer's disease genetics converges on microglial and neuronal dysregulation.
Nature·October 28, 2026·PMID 42951976
Why it mattersAlzheimer's disease genetic risk has been underestimated; this study nearly triples the known common-variant heritability and pinpoints microglial and neuronal pathways as central. The newly identified loci and prioritized drug targets provide a stronger foundation for therapeutic development and polygenic risk prediction in diverse populations.
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