Basic Sciencemoderate evidence
Chaperone-mediated autophagy supports organ regeneration and fibroblast quiescence in mouse models of fibrosis.
Science translational medicine·February 18, 2026·PMID 41706873
Why it mattersOrgan fibrosis lacks therapies that simultaneously target defective parenchymal regeneration and excessive fibroblast activation. This paper identifies LAMP2A as a broad-spectrum antifibrotic factor that addresses both pathological cell types, offering a novel dual-target strategy potentially applicable across multiple fibrotic diseases.
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