Meta-Analysishigh evidence
The Impact of Glucagon-Like Peptide-1 Receptor Agonist Use on Clinical Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis of 346,899 Patients.
The Journal of arthroplasty·June 1, 2026·PMID 41072556
Why it mattersGLP-1RAs are increasingly used for weight loss and diabetes control in arthroplasty patients, but safety concerns about aspiration persist. This analysis provides reassurance on pulmonary safety while highlighting a potential cardiovascular signal that warrants attention in preoperative optimization.
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