Randomized Trialhigh evidence
Safety and efficacy of decompressive craniectomy versus standard craniotomy for large acute epidural haematoma with tentorial herniation in China (PREDICT-AEDH): a nationwide, multicentre, open-label, parallel-group, randomised controlled trial.
The Lancet. Neurology·July 1, 2026·PMID 42309085
Why it mattersThis trial provides high-level evidence directly addressing a common clinical dilemma in neurotrauma: whether to perform primary decompressive craniectomy for large epidural hematomas with herniation. The findings challenge the assumption that more aggressive surgery improves outcomes and highlight a specific safety concern.
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