Cohort Studymoderate evidence
Phosphorylated toll-like receptor 4 defines a high-risk sepsis endotype.
Critical care (London, England)·May 30, 2026·PMID 42218524
Why it mattersSepsis trials targeting TLR4 have failed, possibly due to unselected patient populations. This study identifies a subgroup with heightened TLR4 activation and poor outcomes, supporting biomarker-guided enrichment for future anti-TLR4 therapies.
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