Randomized Trialhigh evidence
Weight Regain Reverses Caloric Restriction-Induced Benefits on the Insulin-IGF-1 Nutrient-Sensing Pathway: Post Hoc Analysis From the CALERIE-2 Randomized Controlled Trial.
Diabetes care·May 1, 2026·PMID 41838032
Why it mattersFor clinicians counseling patients on caloric restriction or weight-loss programs, the durability of weight loss appears more important than the initial magnitude of loss. Regain may blunt favorable effects on insulin resistance, diabetes-related risk markers, and aging-associated biology.
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