Effects of 5:2 intermittent fasting meal replacement on body composition and abdominal fat distribution in overweight and obese adults with early type 2 diabetes.

Clinical nutrition (Edinburgh, Scotland)·February 1, 2026·PMID 41485450

Why it matters

For clinicians managing early type 2 diabetes with obesity, this trial suggests a structured 5:2 meal-replacement program can reduce central adiposity and overall fat mass more than metformin or empagliflozin over 16 weeks, which may be relevant when weight and abdominal fat reduction are primary treatment goals.