Randomized Trialhigh evidence
Adjunctive Intra-Arterial Alteplase After Successful Thrombectomy for Acute Ischemic Stroke: The CHOICE-2 Randomized Clinical Trial.
JAMA·June 2, 2026·PMID 42096239
Why it mattersDespite high recanalization rates with thrombectomy, many patients have incomplete microvascular reperfusion and suboptimal recovery. This trial provides evidence that adjunctive intra-arterial alteplase may improve functional outcomes, but the mortality signal requires careful consideration.
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