Randomized Trialhigh evidence

Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction.

The New England journal of medicine·November 13, 2025·PMID 40888702

Why it matters

Current beta-blocker recommendations post-MI with preserved EF rely on older trials predating modern reperfusion and pharmacotherapy. This large, contemporary trial provides high-quality evidence that routine beta-blocker use may not improve outcomes in this population, potentially simplifying post-MI regimens.

Infographic summary of Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction.
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