Basic Sciencemoderate evidence
Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling.
Cell·September 4, 2025·PMID 40494346
Why it mattersIt reveals a conserved epithelial-mesenchymal feedback loop driven by rare neuroendocrine cells that could be targeted for regenerative therapies in lung injury and diabetes. The link to human diabetes risk with Hedgehog inhibitors adds clinical relevance.
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