Cohort Studymoderate evidence
Neurological outcome of out-of-hospital cardiac arrest patients ventilated with continuous flow insufflation of oxygen: a multicenter observational study.
Resuscitation·August 1, 2026·PMID 42069041
Why it mattersCFIO devices were designed to reduce chest compression interruptions, but this large registry-based study raises concern that they may worsen neurological outcomes compared to standard BVM ventilation. Emergency physicians and EMS directors should reconsider routine CFIO use pending further evidence.

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